Antipyrine is one of the drugs that induce leucocytosis, similar to ergotin, salicylates, and tuberculin. Acts especially on the vaso-motor centers, causing dilation of capillaries of skin and consequent circumscribed patches of hyperemia and swelling. In large doses causes profuse perspiration, dizziness, cyanosis, and somnolence, albumen and blood in urine. Acute erythema multiforme.

Dose.--Second decimal potency.

Ears.--Pains and buzzing. Tinnitus.

Eyes.--Puffiness of lids. Conjunctiva red and edematous, with lachrymation. Red spots (Apis).

Face.--edema and puffiness. Red and swollen.

Female.--Itching and burning in vagina. Menses suppressed. Watery leucorrhea.

Head.--Throbbing headache; sensation of constriction. Flashes of heat. Headache under ears with earache.

Heart.--Faintness, with sensation of stoppage of heart. Throbbing throughout the body. Rapid, weak, irregular pulse.

Mind.--Fear of becoming insane; nervous anxiety; hallucinations of sight and hearing.

Mouth.--Swelling of lips. Burning of mouth and gums. Ulceration of lips and tongue; vesicles and bulle. Small lump in cheek. Tongue swollen. Bloody saliva. Toothache along lower jaw.

Nerves.--Epileptiform seizures. Contractures. Trembling and cramps. Crawling and numbness. General prostration.

Respiratory.--Fluent coryza. Nasal mucous membrane swollen. Dull pains in frontal sinus. Aphonia. Oppression and dyspnea. Cheyne-Stokes respiration.

Skin.--Erythema, eczema, pemphigus. Intense pruritus. Urticaria, appearing and disappearing suddenly, with internal coldness. Angioneurotic-edema. Dark blotches on skin of penis, sometimes with edema.

Stomach.--Nausea and vomiting; burning and pain.

Throat.--Pain on swallowing. Expectoration of fetid pus. Abscess, white false membrane. Sensation of burning.

Urine.--Diminished. Penis black.